The Tough Tech problem we are solving
Autoimmune diseases affect hundreds of millions of people worldwide, arising when the immune system mistakenly attacks the body’s own tissues. Current therapies often suppress immune function broadly, leaving patients vulnerable to infections and long-term side effects while failing to address the root cause—the breakdown of immune tolerance. A key challenge has been retraining the immune system to distinguish self from non-self, a process that naturally occurs in the thymus but cannot easily be replicated or restored once disrupted.
About our solution
Zag Bio is pioneering a new approach to treating autoimmunity by targeting the thymus, the organ responsible for educating immune cells to maintain self-tolerance. Using proprietary bifunctional antibodies, Zag Bio delivers self-antigens to specialized thymic antigen-presenting cells, teaching developing immune cells to recognize and protect the body’s own tissues. This approach reestablishes natural immune balance by generating regulatory T cells that migrate to diseased tissues and restore local tolerance. By leveraging the body’s intrinsic immune-training mechanisms, Zag Bio aims to redefine how autoimmune diseases are treated—replacing suppression with restoration.